Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets
نویسندگان
چکیده
منابع مشابه
Therapeutic Targets in Inflammatory Bowel Disease: Current and Future
IBD ETIOLOGY AND PATHOGENESIS Infl ammatory bowel disease (IBD) is a collection of disorders characterized by idiopathic infl ammation of the gastrointestinal tract. Although primarily classifi ed as either ulcerative colitis (UC) or Crohn’s disease (CD), the presentation of IBD can vary in terms of clinical symptoms, including location of disease involvement, disease severity, age at diagnosis...
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The incidence and prevalence of Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), are rising. According to some estimates >1 million new cases of IBD arise in the United States annually. The conventional therapies available for IBD range from anti-inflammatory drugs to immunosuppressive agents, but these therapies generally fail to achieve satisfac...
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In the last decade, biologic agents, in particular infliximab and adalimum-ab, have deeply changed the therapeutic armamentarium of inflammatory bowel disease (IBD). However, these drugs have a number of contraindications and side-effects that physicians should know so to avoid and eventually manage them. Another important issue is the early introduction of immunomodulators and biologics in the...
متن کاملTherapeutic drug monitoring in inflammatory bowel disease
PURPOSE OF REVIEW There are an expanding number of therapies available to treat pediatric inflammatory bowel disease (IBD). As pediatric gastroenterologists attempt to achieve complete intestinal mucosal healing for their patients, it has become more important to gain an understanding of how to maximize the efficacy of our medications while minimizing their toxicities. We aim to provide an over...
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Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2013
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2012.4530